How reproducible are real-world studies using clinical practice data?
That is the question posed by a paper by Wang, Sreedhara and Schneeweiss (2022). The authors replicate the findings from n=250 real-world data studies. The studies were replicated using 3 datasets: (i) Optum Clinformatics claims data, (ii) IBM MarketScan Research Database claims data, Medicare fee-for-service claims data, and (iii) CPRD electronic health records. Key paper…