Unbiased Analysis of Today's Healthcare Issues
In drug development, clinical trials typically aim for a population that is representative of the patients who would be eligible for the treatment. While randomized controlled trials (RCTs) typically focus on measuring the average health impact of a drug across this population, a paper Basu and Gurjal (2020) argue that treatment effect heterogeneity and self-selection…
That is the title of my latest article in Pharmaceutical Market Europe. An excerpt is below. Randomised controlled trials (RCTs) are regarded as the gold standard of scientific evidence, and for good reason. By randomizsing a treatment across study arms, RCTs eliminate patient-treamtent selection bias, resulting in reliable causal inference. In contrast, in the real…
Is your randomized controlled trial (RCT) generalizable to the general population? This question is known as external validity and is a major issue for a number of treatments. Sometimes, a treatment is very effective in an RCT, but less so in the real world. One reason why this may be the case is that the…
Randomized clinical trials (RCTs) are the “gold standard” for medical studies. Nevertheless, even RCTs have their problems. An NBER working paper by Ludwig, Marcotte and Norberg points highlights some of these issues. The authors examine whether or not anti-depressants reduce suicide rates (they find that anti-depressants do reduce suicide rates). Unfortunately, using data from RCTs…